Efficacy of Live Attenuated and Inactivated Influenza Vaccines in Schoolchildren and Their Unvaccinated Contacts in Novgorod, Russia
Identifieur interne : 001E85 ( Main/Exploration ); précédent : 001E84; suivant : 001E86Efficacy of Live Attenuated and Inactivated Influenza Vaccines in Schoolchildren and Their Unvaccinated Contacts in Novgorod, Russia
Auteurs : L. G. Rudenko [Suisse] ; A. N. Slepushkin [Suisse] ; A. S. Monto [Suisse] ; A. P. Kendal [Suisse] ; E. P. Grigorieva [Suisse] ; E. P. Burtseva [Suisse] ; A. R. Rekstin [Suisse] ; A. L. Beljaev [Suisse] ; V. E. Bragina [Suisse] ; N. Cox [Suisse] ; Y. Z. Ghendon [Suisse] ; G. I. Alexandrova Alexandrova [Suisse]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1993.
Abstract
Children aged 7–14 years in Novgorod, Russia, were given Russian live cold-adapted or inactivated influenza vaccines or placebo over a 2-year period. Schools were randomly assigned as a whole to one of the preparations. In the first year, the vaccines were bivalent, containing types A (H3N2) and A (H1N1) components. In the second year, the vaccines also contained a type B component. In the first year, all viruses isolated were type A (H3N2); in the second, about three-quarters of the isolates were type B and the rest type A (H1N1). During both years, the vaccines protected the vaccinated children. Where significant differences existed, the live attenuated vaccine was more protective than the inactivated. Vaccination rates in schools in which live attenuated vaccines had been used were inversely related to illness rates of staffand unvaccinated children, suggesting that viral transmission had been reduced by the vaccine.
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DOI: 10.1093/infdis/168.4.881
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Ivanovsky Research Institute of Virology, RAMS, Moscow, Ann Arbor, Atlanta, Georgia, Denmark, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Alexandrova, G I Alexandrova" sort="Alexandrova, G I Alexandrova" uniqKey="Alexandrova G" first="G. I. Alexandrova" last="Alexandrova">G. I. Alexandrova Alexandrova</name><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Research Institute of Experimental Medicine, Russian Academy of Medical Sciences (RAMS), St. Petersburg, D. I. Ivanovsky Research Institute of Virology, RAMS, Moscow, Ann Arbor, Atlanta, Georgia, Denmark, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1993-10">1993</date><biblScope unit="vol">168</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="881">881</biblScope><biblScope unit="page" to="887">887</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Children aged 7–14 years in Novgorod, Russia, were given Russian live cold-adapted or inactivated influenza vaccines or placebo over a 2-year period. Schools were randomly assigned as a whole to one of the preparations. In the first year, the vaccines were bivalent, containing types A (H3N2) and A (H1N1) components. In the second year, the vaccines also contained a type B component. In the first year, all viruses isolated were type A (H3N2); in the second, about three-quarters of the isolates were type B and the rest type A (H1N1). During both years, the vaccines protected the vaccinated children. Where significant differences existed, the live attenuated vaccine was more protective than the inactivated. Vaccination rates in schools in which live attenuated vaccines had been used were inversely related to illness rates of staffand unvaccinated children, suggesting that viral transmission had been reduced by the vaccine.</div></front></TEI><affiliations><list><country><li>Suisse</li></country></list><tree><country name="Suisse"><noRegion><name sortKey="Rudenko, L G" sort="Rudenko, L G" uniqKey="Rudenko L" first="L. G." last="Rudenko">L. G. Rudenko</name></noRegion><name sortKey="Alexandrova, G I Alexandrova" sort="Alexandrova, G I Alexandrova" uniqKey="Alexandrova G" first="G. I. Alexandrova" last="Alexandrova">G. I. Alexandrova Alexandrova</name><name sortKey="Beljaev, A L" sort="Beljaev, A L" uniqKey="Beljaev A" first="A. L." last="Beljaev">A. L. Beljaev</name><name sortKey="Bragina, V E" sort="Bragina, V E" uniqKey="Bragina V" first="V. E." last="Bragina">V. E. Bragina</name><name sortKey="Burtseva, E P" sort="Burtseva, E P" uniqKey="Burtseva E" first="E. P." last="Burtseva">E. P. Burtseva</name><name sortKey="Cox, N" sort="Cox, N" uniqKey="Cox N" first="N." last="Cox">N. Cox</name><name sortKey="Ghendon, Y Z" sort="Ghendon, Y Z" uniqKey="Ghendon Y" first="Y. Z." last="Ghendon">Y. Z. Ghendon</name><name sortKey="Grigorieva, E P" sort="Grigorieva, E P" uniqKey="Grigorieva E" first="E. P." last="Grigorieva">E. P. Grigorieva</name><name sortKey="Kendal, A P" sort="Kendal, A P" uniqKey="Kendal A" first="A. P." last="Kendal">A. P. Kendal</name><name sortKey="Monto, A S" sort="Monto, A S" uniqKey="Monto A" first="A. S." last="Monto">A. S. Monto</name><name sortKey="Rekstin, A R" sort="Rekstin, A R" uniqKey="Rekstin A" first="A. R." last="Rekstin">A. R. Rekstin</name><name sortKey="Slepushkin, A N" sort="Slepushkin, A N" uniqKey="Slepushkin A" first="A. N." last="Slepushkin">A. N. Slepushkin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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